This study, the methanol extracts of Salvia verticillata L subsp. amasiaca (Freyn & Bornm) Bornm. and Phlomis pungens Willd. var. hirta Velen from flowers and leaves have been studied for antimicrobial activity. Antibacterial activity of the methanol extracts was determined against 9 bacterial strains (Klebsiella pneumoniae ATCC 4352, Pseudomonas aeroginosa ATCC 27853, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 29213. Staphylococcus epidermidis ATCC 12228. Bacillus cereus ATCC 11778. Salmonella enteritidis KUEN 349, Proteus mirabilis CCM 1944, Escherichia coli ATCC 25922) using the macro broth dilution method. The methanol extract of the leaves and flowers of Salvia verticillata remarkably inhibited the growth of Pseudomonas aeruginosa, Salmonella enteritidis, Escherichia coli. Bacillus cereus. Bacillus subtilis and Staphylococcus aureus. On the other hand. the results indicate that the methanol extract of the leaves and flowers of Phlomis pungens remarkably inhibited the growth of Pseudomonas aeruginosa and Bacillus subtilis. In conclusion. the results show that Salvia verticillata and Phlomis pungens methanol extracts might be an alternative to antimicrobials in various infectious diseases.