Injuries to the orofacial region may vary from localized injuries to extensive soft and hard tissue loss. In addition to physical and psychologic damages, functional and aesthetic aspects must be restored. This clinical report describes the rehabilitation of a patient with a mandibular defect caused by a gunshot wound. Rehabilitation of this patient, with the use of an overdenture prosthesis, was performed after mandibular surgical hard and soft tissue reconstruction. A maxillary total prosthesis and an implant-supported mandibular overdenture supported by 4 osseointegrated implants were fabricated. Despite limited mouth opening and anatomic deficiencies, the patient's aesthetic and functional demands were fulfilled.