Effects of Exosomes on Major Pathways Promote Tumor Formation and Progression

Köse M. E., Aydin B., Geyik C., Geyik Ö. G., Ulukaya E.

Current Molecular Medicine, vol.22, no.6, pp.491-505, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.2174/1566524021666210902113824
  • Journal Name: Current Molecular Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.491-505
  • Keywords: Extracellular vesicles, oncosome, EMT, cancer metabolism, drug resistance, survival, proliferation, exosomal crosstalk, COLORECTAL-CANCER, EXTRACELLULAR VESICLE, CELL-PROLIFERATION, DRUG-RESISTANCE, APOPTOSIS, FIBROBLASTS, METABOLISM, EMT, MECHANISMS, BIOLOGY
  • Istanbul University Affiliated: No

Abstract

© 2022 Bentham Science Publishers.Exosomal vesicles enclose and carry a broad range of biological molecules, such as nucleic acids, lipids, and proteins, and transfer them between cells. In cancer, cells being mentioned could be neighbors in the same tumor microenvironment communicating with each other, or they could be localized at distant sites of the body, enabling suitable conditions for metastasis. Either way, it is a concrete fact that cells under physiological or pathological conditions make crosstalk via exosomal secretion. This review looks at the relation between exosomal cargo and mechanisms of cancer through recent research.