Efficacy of anakinra treatment in a patient with colchicine-resistant familial Mediterranean fever

Alpay N., Sumnu A., Caliskan Y., Yazici H., Turkmen A., Gül A.

RHEUMATOLOGY INTERNATIONAL, vol.32, no.10, pp.3277-3279, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 10
  • Publication Date: 2012
  • Doi Number: 10.1007/s00296-010-1474-6
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3277-3279
  • Keywords: Familial Mediterranean fever, Anakinra, Renal transplantation, Amyloidosis
  • Istanbul University Affiliated: Yes


Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. The serious complication of FMF is AA-type amyloidosis, which can result in end-stage renal disease. Although colchicine is effective in the majority of patients, there is no established treatment for those who are resistant or intolerant to colchicine. We herein report the efficacy of anakinra in a 52-year-old Turkish patient with FMF, secondary amyloidosis and renal transplant, who was resistant to colchicine treatment.