Nerve Growth Factor Neutralization Suppresses beta-Cell Proliferation Through Activin A and Betacellulin

Gezginci-Oktayoglu S., Karatug A., Bolkent S.

PANCREAS, vol.44, no.2, pp.243-249, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1097/mpa.0000000000000243
  • Journal Name: PANCREAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.243-249
  • Istanbul University Affiliated: Yes

Abstract

Objective: The aim of this study was to investigate the effects of nerve growth factor (NGF) neutralization on synthesis and secretion of activin A (Act-A) and betacellulin (BTC) from primary beta cells and the importance of these relations for beta-cell proliferation.