Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation

Chen T., Mally A., Ozden S., Chipman J. K.

ENVIRONMENTAL HEALTH PERSPECTIVES, vol.118, no.11, pp.1597-1602, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 11
  • Publication Date: 2010
  • Doi Number: 10.1289/ehp.1002153
  • Journal Name: ENVIRONMENTAL HEALTH PERSPECTIVES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1597-1602
  • Keywords: carcinogenicity, DNA methylation, epigenetic, furan, gene expression, liver, miRNA, INTRAHEPATIC CHOLANGIOCARCINOMA, FISCHER-344 RATS, MULTIPLE GENES, B6C3F1 MICE, EARLY EVENT, IN-VIVO, GENOTOXICITY, MICRORNAS, HYPOMETHYLATION, PROLIFERATION
  • Istanbul University Affiliated: Yes

Abstract

BACKGROUND: Evidence of potent rodent carcinogenicity via an unclear mechanism suggests that furan in various foods [leading to an intake of up to 3.5 mu g/kg body weight (bw)/day] may present a potential risk to human health.