Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation

Chen T., Mally A., Ozden S., Chipman J. K.

ENVIRONMENTAL HEALTH PERSPECTIVES, cilt.118, sa.11, ss.1597-1602, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 118 Sayı: 11
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1289/ehp.1002153
  • Dergi Adı: ENVIRONMENTAL HEALTH PERSPECTIVES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1597-1602
  • Anahtar Kelimeler: carcinogenicity, DNA methylation, epigenetic, furan, gene expression, liver, miRNA, INTRAHEPATIC CHOLANGIOCARCINOMA, FISCHER-344 RATS, MULTIPLE GENES, B6C3F1 MICE, EARLY EVENT, IN-VIVO, GENOTOXICITY, MICRORNAS, HYPOMETHYLATION, PROLIFERATION
  • İstanbul Üniversitesi Adresli: Evet

Özet

BACKGROUND: Evidence of potent rodent carcinogenicity via an unclear mechanism suggests that furan in various foods [leading to an intake of up to 3.5 mu g/kg body weight (bw)/day] may present a potential risk to human health.