Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation

Chen, Tao; Mally, Angela; Ozden, SİBEL; Chipman, J.

doi:10.1289/ehp.1002153

Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation

Chen T., Mally A., Ozden S., Chipman J. K.

ENVIRONMENTAL HEALTH PERSPECTIVES, cilt.118, sa.11, ss.1597-1602, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 118 Sayı: 11
Basım Tarihi: 2010
Doi Numarası: 10.1289/ehp.1002153
Dergi Adı: ENVIRONMENTAL HEALTH PERSPECTIVES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1597-1602
Anahtar Kelimeler: carcinogenicity, DNA methylation, epigenetic, furan, gene expression, liver, miRNA, INTRAHEPATIC CHOLANGIOCARCINOMA, FISCHER-344 RATS, MULTIPLE GENES, B6C3F1 MICE, EARLY EVENT, IN-VIVO, GENOTOXICITY, MICRORNAS, HYPOMETHYLATION, PROLIFERATION
İstanbul Üniversitesi Adresli: Evet

Özet

BACKGROUND: Evidence of potent rodent carcinogenicity via an unclear mechanism suggests that furan in various foods [leading to an intake of up to 3.5 mu g/kg body weight (bw)/day] may present a potential risk to human health.