Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

Sokmen, Bahar; Aydin, Gulsah; Gumus, Arzu; Karadeniz, Seref; Ugras, Halil; Yanardag, Refiye; Cakir, Umit

doi:10.3109/14756366.2012.692086

Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

Atıf İçin Kopyala

Sokmen B. B., Aydin G., Gumus A., Karadeniz S., Ugras H. I., Yanardag R., ...Daha Fazla

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.28, sa.4, ss.870-875, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 28 Sayı: 4
Basım Tarihi: 2013
Doi Numarası: 10.3109/14756366.2012.692086
Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.870-875
İstanbul Üniversitesi Adresli: Evet

Özet

A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2-picrylhydrazil (DPPH.) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase activites.