Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the

Agarwal, Aniruddha; Agrawal, Rupesh; Raje, Dhananjay; Testi, Ilaria; Mahajan, Sarakshi; Gunasekeran, Dinesh; Aggarwal, Kanika; Murthy, Somasheila; Westcott, Mark; Chee, Soon-Phaik; Mccluskey, Peter; Ho, Su; Teoh, Stephen; Cimino, Luca; Biswas, Jyotirmay; Narain, Shishir; Agarwal, Manisha; Mahendradas, Padmamalini; Khairallah, Moncef; Jones, Nicholas; Tugal-Tutkun, Nuriye; Babu, Kalpana; Basu, Soumayava; Carreno, Ester; Lee, Richard; Al-Dhibi, Hassan; Bodaghi, Bahram; Invernizzi, Alessandro; Goldstein, Debra; Herbort, Carl; Barisani-Asenbauer, Talin; Gonzalez-Lopez, Julio; Androudi, Sofia; Bansal, Reema; Moharana, Bruttendu; Degli Esposti, Simona; Tasiopoulou, Anastasia; Nadarajah, Sengal; Agarwal, Mamta; Abraham, Sharanya; Vala, Ruchi; Singh, Ramandeep; Sharma, Aman; Sharma, Kusum; Zierhut, Manfred; Kon, Onn; Cunningham, Emmett; Kempen, John; Quan Dong Nguyen, Quan; Pavesio, Carlos; Gupta, Vishali

doi:10.1080/09273948.2020.1761401

Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the "Cure" in Ocular Tuberculosis

Agarwal A., Agrawal R., Raje D., Testi I., Mahajan S., Gunasekeran D. V., ...More

OCULAR IMMUNOLOGY AND INFLAMMATION, vol.28, pp.65-73, 2020 (SCI-Expanded)

Publication Type: Article / Article
Volume: 28
Publication Date: 2020
Doi Number: 10.1080/09273948.2020.1761401
Journal Name: OCULAR IMMUNOLOGY AND INFLAMMATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
Page Numbers: pp.65-73
Keywords: Ocular tuberculosis, uveitis, antitubercular therapy, tuberculous, tubercular uveitis, cure, Collaborative Ocular Tuberculosis Study (COTS) group, UVEITIS
Istanbul University Affiliated: Yes

Abstract

Purpose To report the clinical findings, anatomical features, and treatment outcomes in subjects with ocular tuberculosis (OTB) at 24 months in the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods Of the 945 subjects included in COTS-1, those who completed a 24-month follow-up after completion of treatment were included. The main outcome measure was a number of patients with treatment failure (TF). Results 228 subjects (120 males; mean age of 42.82 +/- 14.73 years) were included. Most common phenotype of uveitis was posterior (n= 81; 35.53%), and panuveitis (n= 76; 33.33%). Fifty-two patients (22.81%) had TF. On univariable analysis, odds of high TF was observed with bilaterality (OR: 3.46,p= .003), vitreous haze (OR: 2.14,p= .018), and use of immunosuppressive therapies (OR: 5.45,p= .003). However, only bilaterality was significant in the multiple regression model (OR: 2.84;p= .02). Conclusions Majority of subjects (>75%) achieved cure in the COTS-1 at 24-month follow-up. The concept of "cure" may be a valuable clinical endpoint in trials for OTB.