Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the "Cure" in Ocular Tuberculosis

Agarwal A., Agrawal R., Raje D., Testi I., Mahajan S., Gunasekeran D. V., ...Daha Fazla

OCULAR IMMUNOLOGY AND INFLAMMATION, cilt.28, ss.65-73, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/09273948.2020.1761401
  • Dergi Adı: OCULAR IMMUNOLOGY AND INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.65-73
  • Anahtar Kelimeler: Ocular tuberculosis, uveitis, antitubercular therapy, tuberculous, tubercular uveitis, cure, Collaborative Ocular Tuberculosis Study (COTS) group, UVEITIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose To report the clinical findings, anatomical features, and treatment outcomes in subjects with ocular tuberculosis (OTB) at 24 months in the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods Of the 945 subjects included in COTS-1, those who completed a 24-month follow-up after completion of treatment were included. The main outcome measure was a number of patients with treatment failure (TF). Results 228 subjects (120 males; mean age of 42.82 +/- 14.73 years) were included. Most common phenotype of uveitis was posterior (n= 81; 35.53%), and panuveitis (n= 76; 33.33%). Fifty-two patients (22.81%) had TF. On univariable analysis, odds of high TF was observed with bilaterality (OR: 3.46,p= .003), vitreous haze (OR: 2.14,p= .018), and use of immunosuppressive therapies (OR: 5.45,p= .003). However, only bilaterality was significant in the multiple regression model (OR: 2.84;p= .02). Conclusions Majority of subjects (>75%) achieved cure in the COTS-1 at 24-month follow-up. The concept of "cure" may be a valuable clinical endpoint in trials for OTB.