Proatherogenic Importance of Carbamylation-induced Protein Damage and Type 2 Diabetes Mellitus: A Systematic Review

Simsek B., Yanar K., Cakatay U.

CURRENT DIABETES REVIEWS, vol.16, no.6, pp.608-618, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 16 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.2174/1573399816666200107102918
  • Journal Name: CURRENT DIABETES REVIEWS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.608-618
  • Istanbul University Affiliated: Yes

Abstract

Introduction & Background: Protein carbamylation is a non-enzymatic and irreversible posttranslational process. It affects functions of numerous enzymes, hormones and receptors playing several roles in diabetes pathogenesis by changing their native structures. Detrimental consequences of oxidative protein damage comprise, but are not limited to glyoxidation, lipoxidation and carbonylation reactions. Since the carbamylated plasma proteins are strongly related to the glycemic control parameters of diabetes, they may have an additive value and emerge as potential biomarkers for the follow up, prognosis and treatment of diabetes mellitus.