GLM analysis of time resolved NIRS data of motor activation during different motor tasks

Molteni E., Wabnitz H., Bianchi A. M., Steinkellner O., Sander-Thoemmes T., Geisler F., ...More

35th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Osaka, Japan, 3 - 07 July 2013, pp.1787-1790 identifier

  • Publication Type: Conference Paper / Full Text
  • City: Osaka
  • Country: Japan
  • Page Numbers: pp.1787-1790
  • Istanbul University Affiliated: No


The hemodynamic response to motor activation was investigated by time-resolved NIRS in healthy subjects and patients with unilateral impairment in motor ability. Healthy subjects performed a simple and a complex finger movement task, patients a handgrip task. A General Linear Model approach (GLM) was applied during NIRS data processing. In general, compared to the integral (continuous wave signal), higher significance of activation was found for the variance signal that selectively represents changes in the deep compartment. A discussion of GLM results with respect to task complexity and difficulty is provided.