The present study was performed to evaluate the in vitro antimicrobial and antioxidant properties of various extracts (hexane, dichloromethane, methanol/chloroform, methanol/water and direct methanol) from Salvia microstegia (Boiss.) Et. Bal., a member of Lamiaceae family. Direct methanol extracts of S. microstegia exhibited more effective antibacterial activities on the Gram-negative and Gram-positive bacteria. None of the extracts exhibited any antifungal activities on the Candida albicans ATCC 10231. The total phenolic components of S. microstegia was found 103.64 mg/g gallic acid equivalent. The antioxidant activity of the methanolic extract of S. microstegia was examined with two complementary test systems; 2,2-diphenyl-1-picrylhydrazyl (DPPH) and beta-carotene-linoleic acid assays. The 50% (IC50) inhibition activity of the methanolic extract of S. microstegia on the free radical DPPH was determined as 7.63 mg/ml. In the case of the linoleic acid system, the methanolic extract of S. microstegia showed 79.92% inhibition, this value is quite close to the value of synthetic antioxidant reagent, 92.46%.