Assessment of rewarding and reinforcing properties of biperiden in conditioned place preference in rats

Allahverdiyev O., Nurten A., Enginar N.

BEHAVIOURAL BRAIN RESEARCH, cilt.225, sa.2, ss.642-645, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 225 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.bbr.2011.07.050
  • Dergi Adı: BEHAVIOURAL BRAIN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.642-645
  • İstanbul Üniversitesi Adresli: Evet

Özet

Biperiden is one of the most commonly abused anticholinergic drugs. This study assessed its motivational effects in the acquisition of conditioned place preference in rats. Biperiden neither produced place conditioning itself nor enhanced the rewarding effect of morphine. Furthermore, biperiden in combination with haloperidol also did not affect place preference. These findings suggest that biperiden seems devoid of abuse potential properties at least at the doses used. (C) 2011 Elsevier B.V. All rights reserved.