Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo

Yildirim S., Altun S., Gumushan H., Patel A., Djamgoz M. B. A.

CANCER LETTERS, vol.323, no.1, pp.58-61, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 323 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1016/j.canlet.2012.03.036
  • Journal Name: CANCER LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.58-61
  • Istanbul University Affiliated: Yes


Epigenetic upregulation of voltage-gated sodium channels (VGSCs) has been reported in a number of carcinoma cell lines and tissues. Furthermore, a large body of experimental evidence suggested that functional VGSC expression enhances various in vitro cell behaviours, such as directional motility, that would be involved in the metastatic cascade. However, it is not known if VGSC activity promotes metastasis in vivo. Here, using the Copenhagen rat model of prostate cancer and blocking VGSC activity in primary tumours with tetrodotoxin, we show (1) that the number of lung metastasis is reduced by >40% and (2) that lifespan is significantly improved. (C) 2012 Elsevier Ireland Ltd. All rights reserved.