In vitro effects of vitamin C and selenium on NK activity of patients with beta-thalassemia major
PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.23, sa.3, ss.187-197, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 3
- Basım Tarihi: 2006
- Doi Numarası: 10.1080/08880010500506420
- Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.187-197
- Anahtar Kelimeler: antioxidant, NK activity, oxidative stress, selenium, beta-thalassemia, vitamin C
- İstanbul Üniversitesi Adresli: Evet
Özet
In this study, the in vitro effects of vitamin C and selenium on natural killer (NK) cell activity of beta-thalassemia major patients was investigated. At first, significant decreased NK activity was found at E:T ratios of 1:1, 5:1, and 10:1 in whole thalassemia patients. Low-dose selenium treatment enhanced NK activity in patients but there was no change in the control group. High-dose selenium decreased NK activity significantly in splenectomized patients. Different doses vitamin C enhanced NK activity significantly in both splenectomized and unsplenectomized patients. According to these results, selenium dosage should be arranged carefully in thalassemia patients, whereas vitamin C can be used confidently.