Extending Amyloidosis Diagnosis: A Rare Case of Peritoneal AL Amyloidosis Revealed by 18F-FDG PET/CT and 99mTc-PYP SPECT/CT

Arslan D. F., Inal E., Isik E. G., Sanli Y.

Clinical Nuclear Medicine, cilt.50, sa.3, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1097/rlu.0000000000005603
  • Dergi Adı: Clinical Nuclear Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Anahtar Kelimeler: 18F-FDG PET/CT, 99mTc-PYP scintigraphy, AL amyloidosis, peritoneal amyloidosis
  • İstanbul Üniversitesi Adresli: Evet

Özet

We present a case with systemic amyloidosis secondary to immunoglobulin light-chain amyloidosis (AL amyloidosis), which 18F-FDG PET/CT and 99mTc-PYP scintigraphy revealed amyloid deposition in the peritoneum, omentum, and mesentery. AL amyloidosis is characterized by the proliferation of clonal plasma cells and increased production and extracellular accumulation of immunoglobulin light chains, leading to organ malfunction. Even though AL amyloidosis can affect the gastrointestinal system, peritoneal involvement is rarely observed. PET/CT and SPECT/CT images showed moderate to slightly increased tracer uptake in affected organs.