Association of pre-eclampsia with hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population

Yılmaz H., Unlucerci Y. M. Y., Gurdol F. M., İşbilen E., İsbir T.

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, vol.44, no.5, pp.423-427, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1479-828x.2004.00283.x
  • Journal Name: AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.423-427
  • Keywords: hyperhomocysteinaemia, methylene tetrahydrofolate reductase gene, pre-eclampsia, Turkish, SERUM HOMOCYST(E)INE LEVELS, FACTOR-V-LEIDEN, VASCULAR-DISEASE, COMMON MUTATION, RISK-FACTOR, CARDIOVASCULAR-DISEASE, HOMOCYSTEINE, PREGNANCY, WOMEN, SUSCEPTIBILITY
  • Istanbul University Affiliated: Yes

Abstract

Background: Hyperhomocysteinaemia is a common finding in a wide variety of pathological conditions that exhibit endothelial disturbances. In the pathogenesis of pre-eclampsia, endothelial cell activation or dysfunction has been proposed as a central feature, and the presence of hyperhomocysteinaemia in varying degrees has been detected. One of the known causes of hyperhomocysteinaemia is polymorphism in the methylenetetrahydrofolate reductase gene that lowers the activity of the enzyme.