Akademik Veri Yönetim Sistemi
4th INTERNATIONAL SCIENTIFIC RESEARCH AND INNOVATION CONGRESS, Bursa, Türkiye, 14 - 16 Aralık 2025, ss.817-826, (Tam Metin Bildiri)
Halophilic actinomycetes are valuable microorganisms from a biotechnological perspective, possessing advanced physiological and biochemical adaptation mechanisms that enable them to survive in extreme environments with high salinity. These bacteria can synthesize organic osmolytes such as glycine betaine, trehalose, and proline to reduce osmotic stress; they also implement unique adjustments in cell wall structures and protein stability that increase salt tolerance. Halophilic actinomycetes isolated from extreme ecosystems are reported to have a wider variety of metabolites compared to other actinobacteria and are particularly producers of undiscovered new secondary metabolites. Recent studies have revealed that these microorganisms can produce compounds with antimicrobial, anticancer, and antioxidant effects, as well as industrially important salt-tolerant enzymes. These enzymes, which can remain active under salt stress, are particularly important in bioindustrial processes and food technology due to their high stabilization properties. Halophilic or halotolerant actinomycetes, which have been studied less frequently than actinobacteria in other habitats, are also known to be effective microorganisms in bioremediation applications such as the remediation of arid lands caused by salinization and the detoxification of pollutants. Furthermore, it is emphasized that metabolites obtained from halophilic actinomycetes offer strong potential in combating pathogens that are developing resistance to an increasing number of antibiotics. This makes halophilic actinomycetes a strategic resource for the discovery of new-generation antimicrobial compounds. This study summarizes the systematic characteristics of halophilic actinomycetes, their salt adaptation mechanisms, and their biotechnologically valuable metabolites; it also discusses potential application areas for future research.