The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

Benli E., AYYıLDıZ S. N. , Cirrik S., Kokturk S. , Cirakoglu A., Noyan T., ...More

INTERNATIONAL BRAZ J UROL, vol.43, no.2, pp.345-355, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1590/s1677-5538.ibju.2016.0075
  • Title of Journal : INTERNATIONAL BRAZ J UROL
  • Page Numbers: pp.345-355


Introduction: Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a septic model induced in rats with cecal ligation and puncture (CLP).