The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

Benli E., AYYıLDıZ S. N., Cirrik S., Kokturk S., Cirakoglu A., Noyan T., ...More

INTERNATIONAL BRAZ J UROL, vol.43, no.2, pp.345-355, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1590/s1677-5538.ibju.2016.0075
  • Journal Name: INTERNATIONAL BRAZ J UROL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.345-355
  • Keywords: Acute Kidney Injury, Tadalafil, Kidney Failure, Chronic, Renal Insufficiency, CECAL LIGATION, SILDENAFIL CITRATE, MECHANISMS, INHIBITORS, MORTALITY, DISEASE
  • Istanbul University Affiliated: No

Abstract

Introduction: Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a septic model induced in rats with cecal ligation and puncture (CLP).