The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

Benli E., AYYıLDıZ S. N., Cirrik S., Kokturk S., Cirakoglu A., Noyan T., ...Daha Fazla

INTERNATIONAL BRAZ J UROL, cilt.43, sa.2, ss.345-355, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1590/s1677-5538.ibju.2016.0075
  • Dergi Adı: INTERNATIONAL BRAZ J UROL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.345-355
  • Anahtar Kelimeler: Acute Kidney Injury, Tadalafil, Kidney Failure, Chronic, Renal Insufficiency, CECAL LIGATION, SILDENAFIL CITRATE, MECHANISMS, INHIBITORS, MORTALITY, DISEASE
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Introduction: Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a septic model induced in rats with cecal ligation and puncture (CLP).