Intraportal Transplantation of Pancreatic Islets in Mouse Model


Khatri R., Hussmann B., Rawat D., Gurol A. O., Linn T.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, no.135, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: Issue: 135
  • Publication Date: 2018
  • Doi Number: 10.3791/57559
  • Journal Name: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Istanbul University Affiliated: Yes

Abstract

Pancreatic islet transplantation to reduce hyperglycemia is highly successful in rodents with chemically-induced diabetes. The most common transplantation site in experimental islet transplantation is the kidney capsule. However, as less is known about the interaction of pancreatic islets with blood constituents, it also makes sense to utilize the portal vein approach in experimental islet transplantation.