Aberrant Activation-Inducec Cyticine Deaminase Gene Expression Links BCR/ABL1-Negative Classical Myeloproliferative Neoplasms

Dermenci H., Aday A., Teker A. B. A., Hancer V. S., Gelmez M. Y., Nalcaci M., ...More

HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, vol.60, no.3, pp.228-233, 2022 (ESCI, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.4274/haseki.galenos.2022.8133
  • Journal Name: HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.228-233
  • Keywords: Cytidine deaminase, mutations, genomic instability, IMMUNOGLOBULIN EXPRESSION, AID, MUTATION, JAK2
  • Istanbul University Affiliated: Yes

Abstract

Aim: Activation-induced cytidine deaminase (AID) has been associated with tumor initiation and development because of its ability to generate DNA damage and somatic mutations that cause genomic instability. This study aimed to investigate the relationship between AID expression levels and the risk of developing BCR/ABL1-negative myeloproliferative neoplasms (MPNs) by comparing the AID expression levels of the patients and controls.