Assessment of platelet aspirin responsiveness in Turkish Population with PFA-100, serum thromboxane B-2, soluble CD40 ligand and soluble P-Selectin]

Saka B., Genc S., Eroglu H., Akpinar T. S., Karadag A., Kilic L., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.38, no.1, pp.63-67, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5505/tjb.2013.75437
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.63-67
  • Keywords: Aspirin resistance, PFA-100, thromboxane B-2, (TXB2), CD40 ligand, sP-selectin, FUNCTION ANALYZER PFA-100, LOW-DOSE ASPIRIN, CARDIOVASCULAR-DISEASE, HEALTHY-VOLUNTEERS, DIABETES-MELLITUS, RESISTANCE, BIOSYNTHESIS, AGGREGATION, VARIABILITY, OMEPRAZOLE
  • Istanbul University Affiliated: Yes

Abstract

Aim: Recurrent thromboembolic vascular events have been reported in 5.5 to 60% of the population despite aspirin therapy. We aimed to determine the frequency of aspirin non-responsiveness in our population with "Platelet Function Analyzer-100 Closure Time" (PFA-100 CT) and serum tromboxane B-2, soluble CD40 Ligand and soluble P-selectin levels.