Polymorphisms of the IL-8 and CXCR2 genes are not associated with Behcet's disease

Duymaz-Tozkir J., Yilmaz V., Uyar F., Hajeer A., Saruhan-Direskeneli G., Gul A.

JOURNAL OF RHEUMATOLOGY, cilt.32, sa.1, ss.93-97, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2005
  • Dergi Adı: JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.93-97
  • Anahtar Kelimeler: interleukin 8, CXCR2, Behcet's disease, gene polymorphism, SUPEROXIDE GENERATION, ENDOTHELIAL-CELLS, INTERLEUKIN-8, NEUTROPHIL, CHEMOKINES, ADHESION, HLA-B51, LOCUS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. Genetic susceptibility to Behcet's disease (BD) is well documented for HLA-B51; however, contribution of other genetic polymorphisms is estimated to be substantial. Interleukin 8 (IL-8), a potent chemoattractant for neutrophils, has been found to be elevated in BD serum, and the serum concentrations correlate with disease activity. Novel polymorphisms in IL-8 (CXCL8) and in one of its receptors, CXCR2 gene, may have a role in enhanced IL-8 activity in BD.