Atıf İçin Kopyala
Duymaz-Tozkir J., Yilmaz V., Uyar F., Hajeer A., Saruhan-Direskeneli G., Gul A.
JOURNAL OF RHEUMATOLOGY, cilt.32, sa.1, ss.93-97, 2005 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
32
Sayı:
1
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Basım Tarihi:
2005
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Dergi Adı:
JOURNAL OF RHEUMATOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.93-97
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Anahtar Kelimeler:
interleukin 8, CXCR2, Behcet's disease, gene polymorphism, SUPEROXIDE GENERATION, ENDOTHELIAL-CELLS, INTERLEUKIN-8, NEUTROPHIL, CHEMOKINES, ADHESION, HLA-B51, LOCUS
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İstanbul Üniversitesi Adresli:
Evet
Özet
Objective. Genetic susceptibility to Behcet's disease (BD) is well documented for HLA-B51; however, contribution of other genetic polymorphisms is estimated to be substantial. Interleukin 8 (IL-8), a potent chemoattractant for neutrophils, has been found to be elevated in BD serum, and the serum concentrations correlate with disease activity. Novel polymorphisms in IL-8 (CXCL8) and in one of its receptors, CXCR2 gene, may have a role in enhanced IL-8 activity in BD.