Polymorphisms of the IL-8 and CXCR2 genes are not associated with Behcet's disease
JOURNAL OF RHEUMATOLOGY, cilt.32, sa.1, ss.93-97, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2005
- Dergi Adı: JOURNAL OF RHEUMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.93-97
- Anahtar Kelimeler: interleukin 8, CXCR2, Behcet's disease, gene polymorphism, SUPEROXIDE GENERATION, ENDOTHELIAL-CELLS, INTERLEUKIN-8, NEUTROPHIL, CHEMOKINES, ADHESION, HLA-B51, LOCUS
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective. Genetic susceptibility to Behcet's disease (BD) is well documented for HLA-B51; however, contribution of other genetic polymorphisms is estimated to be substantial. Interleukin 8 (IL-8), a potent chemoattractant for neutrophils, has been found to be elevated in BD serum, and the serum concentrations correlate with disease activity. Novel polymorphisms in IL-8 (CXCL8) and in one of its receptors, CXCR2 gene, may have a role in enhanced IL-8 activity in BD.