Synthesis, characterization and investigation of antibacterial and antifungal activities of novel 1,3-butadiene compounds
SYNTHETIC COMMUNICATIONS, vol.50, no.21, pp.3234-3244, 2020 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 50 Issue: 21
- Publication Date: 2020
- Doi Number: 10.1080/00397911.2020.1799010
- Journal Name: SYNTHETIC COMMUNICATIONS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, EMBASE
- Page Numbers: pp.3234-3244
- Istanbul University Affiliated: No
Abstract
The nitro group-substituted perhalogenobuta-1,3-diene (1) is important synthetic precursor in the synthesis of different heterocycles groups with high biological activity. Firstly, new N,S-substituted-perhalonitro-1,3-butadiene compounds were synthesized by the reactions of various amino or thiol containing nucleophiles with1. The structures of all new compounds have been identified by using spectroscopic techniques (FT-IR,H-1-NMR,C-13-NMR, MS and microanalysis). Secondly, their antimicrobial properties were tested as potential antibacterial and antifungal agents. Antimicrobial activity of synthesized N,S-substituted perhalonitrobutadienes4a-jand5a-dwas evaluated againstEscherichia coliB-906,Staphylococcus aureus209-P, andMycobacterium luteumB-917 bacteria andCandida tenuisVKM Y-70 andAspergillus nigerF-1119 fungi and the compounds4c,4d,5aand5bwith high antifungal action against test-cultureAspergillus nigerat MIC values 0.9-1.9 mu g/cm(3)were identified as the most potent.