alpha-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals


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Klos K., Ahlskog J., Josephs K., Apaydin H. , Parisi J., Boeve B., ...Daha Fazla

NEUROLOGY, cilt.66, ss.1100-1102, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age ( N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.
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α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

  1. D. W. Dickson, MD

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  1. Address correspondence and reprint requests to Dr. Dennis W. Dickson, Departments of Pathology and Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224; e-mail: dickson.dennis@mayo.edu
  1. doi: 10.1212/01.wnl.0000204179.88955.fa Neurologyvol. 66 no. 7 1100-1102
 
  • Abstract

The authors assessed the frequency of spinal cord α-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using α-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some α-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse α-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.