alpha-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

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Klos K., Ahlskog J., Josephs K., Apaydin H., Parisi J., Boeve B., ...More

NEUROLOGY, vol.66, no.7, pp.1100-1102, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 7
  • Publication Date: 2006
  • Doi Number: 10.1212/01.wnl.0000204179.88955.fa
  • Journal Name: NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1100-1102
  • Istanbul University Affiliated: Yes

Abstract

  • Brief Communications

α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

  1. K. J. Klos, MD,
  2. J. E. Ahlskog, MD, PhD,
  3. K. A. Josephs, MD, MST,
  4. H. Apaydin, MD,
  5. J. E. Parisi, MD,
  6. B. F. Boeve, MD,
  7. M. W. DeLucia, BS and
  8. D. W. Dickson, MD

+Show Affiliations

  1. Address correspondence and reprint requests to Dr. Dennis W. Dickson, Departments of Pathology and Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224; e-mail: dickson.dennis@mayo.edu
  1. doi: 10.1212/01.wnl.0000204179.88955.fa Neurology April 11, 2006 vol. 66 no. 7 1100-1102
 
  • Abstract

The authors assessed the frequency of spinal cord α-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using α-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some α-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse α-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.

 

The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age ( N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.