alpha-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals


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Klos K., Ahlskog J., Josephs K., Apaydin H. , Parisi J., Boeve B., ...More

NEUROLOGY, vol.66, no.7, pp.1100-1102, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 7
  • Publication Date: 2006
  • Doi Number: 10.1212/01.wnl.0000204179.88955.fa
  • Title of Journal : NEUROLOGY
  • Page Numbers: pp.1100-1102

Abstract

  • Brief Communications

α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

  1. D. W. Dickson, MD

+Show Affiliations

  1. Address correspondence and reprint requests to Dr. Dennis W. Dickson, Departments of Pathology and Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224; e-mail: dickson.dennis@mayo.edu
  1. doi: 10.1212/01.wnl.0000204179.88955.fa Neurologyvol. 66 no. 7 1100-1102
 
  • Abstract

The authors assessed the frequency of spinal cord α-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using α-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some α-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse α-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.

 

The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age ( N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.