Association of IL6 with Laboratory Parameters, Obesity, and Osteoporosis in Turkish Geriatric Patients Türk Yaşlı Hastalarda IL6 ile Laboratuvar Parametreleri, Obezite ve Osteoporoz Arasındaki İlişki

Yılmaz D., Şahin E., Ezirmik E., Işıksaçan N., Karandere F., Arslan F.

Medical Journal of Bakirkoy, cilt.21, sa.2, ss.172-180, 2025 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.4274/bmj.galenos.2024.2024.8-12
  • Dergi Adı: Medical Journal of Bakirkoy
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL
  • Sayfa Sayıları: ss.172-180
  • Anahtar Kelimeler: C-reactive protein, inflammatory parameters, Interleukin-6, obesity, osteoporosis
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The cytokine interleukin (IL)-6 is involved in the inflammatory response and has been linked to obesity and osteoporosis, which are public health issues in the geriatric population. Methods: The study included 154 patients, 109 females and 45 males over the age of 65 without any complaints, who visited the internal medicine outpatient clinic at Bakırköy Dr. Sadi Konuk Training and Research Hospital. Femoral neck and lumbar L1-L4 vertebra bone densitometry was measured using dual-energy X-ray absorptiometry. Additionally, body mass index, arm and calf circumference, general laboratory parameters, and IL-6 levels were recorded. Results: A positive correlation was found between IL-6 levels and monocyte and C-reactive protein (CRP) levels. Furthermore, a significant negative correlation was observed between IL-6 and albumin levels (p=0.002, p=0.000, p=0.005). However, no significant relationship was found between IL-6 levels and obesity or osteoporosis. Conclusion: Results showed a significant positive correlation between IL-6 levels and monocyte and CRP levels and a significant negative correlation with albumin levels. However, no significant relationship was found between IL-6 levels and obesity or osteoporosis. Further studies are needed to fully explain the relationship between IL-6 and these health conditions fully.