Ancient familial Mediterranean fever mutations in human pyrin and resistance toYersinia pestis

Park Y. H., Remmers E. F., Lee W., Ombrello A. K., Chung L. K., Zhao Shilei Z. S., ...Daha Fazla

NATURE IMMUNOLOGY, cilt.21, sa.8, ss.857-876, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 8
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1038/s41590-020-0705-6
  • Dergi Adı: NATURE IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.857-876
  • İstanbul Üniversitesi Adresli: Evet

Özet

Familial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin inflammasome. Kastner and colleagues show that mutant pyrin better resists suppression by the plague bacteriumYersinia pestisand may have been positively selected in human Middle Eastern populations.