Ancient familial Mediterranean fever mutations in human pyrin and resistance toYersinia pestis

Park, Yong; Remmers, Elaine; Lee, Wonyong; Ombrello, Amanda; Chung, Lawton; Zhao Shilei, Zhao; Stone, Deborah; Ivanov, Maya; Loeven, Nicole; Barron, Karyl; Hoffmann, Patrycja; Nehrebecky, Michele; Akkaya-Ulum, Yeliz; SAĞ, ERDAL; Balci-Peynircioglu, Banu; Aksentijevich, Ivona; Gül, AHMET; Rotimi, Charles; Chen, Hua; Bliska, James; ÖZEN, SEZA; Kastner, Daniel; Shriner, Daniel; Chae, Jae

doi:10.1038/s41590-020-0705-6

Ancient familial Mediterranean fever mutations in human pyrin and resistance toYersinia pestis

Park Y. H., Remmers E. F., Lee W., Ombrello A. K., Chung L. K., Zhao Shilei Z. S., ...More

NATURE IMMUNOLOGY, vol.21, no.8, pp.857-876, 2020 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 21 Issue: 8
Publication Date: 2020
Doi Number: 10.1038/s41590-020-0705-6
Journal Name: NATURE IMMUNOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Page Numbers: pp.857-876
Istanbul University Affiliated: Yes

Abstract

Familial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin inflammasome. Kastner and colleagues show that mutant pyrin better resists suppression by the plague bacteriumYersinia pestisand may have been positively selected in human Middle Eastern populations.