Investigation of lncRNA H19 in prostate cancer cells and secreted exosomes upon androgen stimulation or androgen receptor blockage

ÖZGÜR E., GEZER U.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.121, no.5, pp.362-365, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_058
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.362-365
  • Keywords: prostate cancer, exosomes, H19, androgen, enzalutamide, LONG NONCODING RNA, EXPRESSION, GENE, ANTAGONIZES, METASTASIS, BIOMARKER, PROMOTES, PRODUCT, IMPACT, GROWTH
  • Istanbul University Affiliated: Yes

Abstract

OBJECTIVES: In the present study, cellular or exosomal expression of H19, an oncofetal lncRNA gene, was evaluated during androgen stimulation via dihydrotestosterone (DHT) or AR blockage via enzalutamide in cultured hormone-sensitive Pca cells which overexpres AR (LNCaP-AR(+)).