Role of Galectins in Allergic Disorders
RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY, cilt.10, sa.1, ss.2-12, 2016 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 1
- Basım Tarihi: 2016
- Doi Numarası: 10.2174/1872213x10666160426152917
- Dergi Adı: RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.2-12
- İstanbul Üniversitesi Adresli: Evet
Özet
Background: Allergen avoidance, pharmacotherapy; with antihistamines, anti-leukotrienes, corticosteroids and bronchodilators as well as monoclonal antibodies; and allergen specific immunotherapy stand as confirmed approaches for the management of allergic disorders as asthma, allergic rhinitis/rhinoconjunctivitis, atopic dermatitis, food allergies and anaphylaxis. Galectins are members of animal lectin protein family, with binding specificity for beta-galactoside sugars. These highly conserved proteins are known to be expressed in various effector cells of the immune system, exert immuno-regulatory activities, and enroll in tissue inflammation and regulation of immune homeostasis.