Association between SDF1-3 ' A or CXCR4 gene polymorphisms with predisposition to and clinicopathological characteristics of prostate cancer with or without metastases

Isman F. K., Kucukgergin C., Dasdemir S., Cakmakoglu B., Sanli O., Seckin S.

MOLECULAR BIOLOGY REPORTS, cilt.39, sa.12, ss.11073-11079, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 12
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s11033-012-2010-4
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.11073-11079
  • Anahtar Kelimeler: SDF-1(CXCL12), CXCR4, Single nucleotide polymorphism, PCR-RFLP analysis, Prostate cancer, CHEMOKINE RECEPTOR CXCR4, BREAST-CANCER, LUNG-CANCER, FACTOR-I, CELL-ADHESION, CXCL12 SDF-1, ORAL-CANCER, EXPRESSION, SUSCEPTIBILITY, ANGIOGENESIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

In the present study, we aimed to investigate the association between SDF1-3'A and CXCR4 gene polymorphisms and the susceptibility and clinicopathological development of prostate cancer. SDF1-3'A and CXCR4 gene polymorphisms were assessed by polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) in 149 healthy subjects and 152 patients with prostate cancer. There were no significant differences in the distributions of SDF-1 and CXCR4 genotypes between controls and prostate cancer patients. However, the patients with AA genotype of SDF1-3'A gene presented a higher risk for developing an advanced disease status as compared to patients with GG homozygotes (aOR = 2.02; 95 % CI = 1.05-3.90; P = 0.035). In addition, the distribution of AA genotype of SDF1-3'A gene was found significantly increased in the patients with bone metastasis in comparison to those without bone metastasis (aOR = 2.94; 95 % CI = 1.26-6.82; P = 0.012). On the other hand, CXCR4 gene polymorphism was not associated with the clinicopathological characteristics of prostate cancer. Our results suggest that SDF1-3'A and CXCR4 gene polymorphisms may not be risk factors for the susceptibility to prostate cancer. However, SDF1-3'A gene polymorphism may be associated with the progression and bone metastasis of prostate cancer in a Turkish men population.