NEPHROPATHY IN THE COURSE OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION - A CLINICOPATHOLOGICAL STUDY

BÜYÜKBABANİ N., DURRBACH A., CHAUVEAU D., TRAWALE J., VIARD J., DIOUF B., ...More

NEPHROLOGIE, vol.14, no.3, pp.143-149, 1993 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 1993
  • Journal Name: NEPHROLOGIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.143-149
  • Keywords: AIDS, HIV-1, FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS, MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS, AZT
  • Istanbul University Affiliated: No

Abstract

We report 16 patients with HIV1 infection with biopsy-proven renal involvement. Nine patients were caucasians and seven were blacks. There were 11 patients at stage II and 5 at stage IV of the HIV1 infection. Three patterns of histologic lesions were found: 6 patients, all blacks, with nephrotic syndrome and/or renal insufficiency had focal and segmental glomerulosclerosis (FSGS) with tubulo-interstitial lesions. In contrast, 6 patients, all caucasians, had various types of glomerulonephritis characterized by immunoglobulin and complement deposits; 3 of them were membranoproliferative glomerulonephritis (MPGN). The four remaining patients had predominant tubulo-interstitial lesions. In three patients who had FSGS, treatment by AZT induced temporary improvement of renal function and hemodialysis could be interrupted for a few months. The cure of infectious foci was followed by improvement in renal signs in two out of the 3 MPGN patients.