Comparative study of coronary artery bypass graft materials: reduced contraction and ADMA levels in internal mammary artery versus saphenous vein.


Ozen G. , Aljesri K., Turkyilmaz G., Turkyilmaz S., Kavala A. A. , Topal G., ...More

The Journal of cardiovascular surgery, vol.63, pp.69-77, 2022 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63
  • Publication Date: 2022
  • Doi Number: 10.23736/s0021-9509.21.11796-3
  • Journal Name: The Journal of cardiovascular surgery
  • Journal Indexes: Science Citation Index Expanded, Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.69-77
  • Keywords: Saphenous vein, Mammary arteries, Blood vessels, Coronary artery bypass, Prostaglandins, Leukotrienes, HEAVY-CHAIN ISOFORM, HUMAN VASCULAR-TONE, CARDIOPULMONARY BYPASS, THORACIC ARTERY, PROSTACYCLIN, REACTIVITY, SURGERY, VASOCONSTRICTION, PATHOPHYSIOLOGY, LEUKOTRIENES

Abstract

BACKGROUND: Vasospasm and atherosclerosis due to low endothelial capacity are the most important causes of coronary artery bypass graft failure observed in internal mammary artery (IMA) and saphenous vein (SV). Vasospasm can be mimicked in in-vitro studies by inducing vasoconstriction of graft materials. In the present study, we aimed to compare the vascular contraction induced by several spasmogens including prostaglandin E2 (PGE(2)), prostaglandin F2 alpha (PGF(2 alpha)), phenylephnne (PE), leukotriene C4 (LTC4), LTD4, potassium chlonde (KCl), and arachidonic acid between IMA and SV preparations. Furthermore, endothelial capacity, nitrite and asymmetric dimethylarginine (ADMA) levels were compared between two grafts.