The Journal of cardiovascular surgery, cilt.63, sa.1, ss.69-77, 2022 (SCI-Expanded)
BACKGROUND: Vasospasm and atherosclerosis due to low endothelial capacity are the most important causes of coronary artery bypass graft failure observed in internal mammary artery (IMA) and saphenous vein (SV). Vasospasm can be mimicked in in-vitro studies by inducing vasoconstriction of graft materials. In the present study, we aimed to compare the vascular contraction induced by several spasmogens including prostaglandin E2 (PGE(2)), prostaglandin F2 alpha (PGF(2 alpha)), phenylephnne (PE), leukotriene C4 (LTC4), LTD4, potassium chlonde (KCl), and arachidonic acid between IMA and SV preparations. Furthermore, endothelial capacity, nitrite and asymmetric dimethylarginine (ADMA) levels were compared between two grafts.