Ileocolonic Lymphonodular Hyperplasia in Children Related to Etiologies Ranging from Food Hypersensitivity to Familial Mediterranean Fever

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ÇAKIR M., Sag E., SAYGIN İ., ORHAN F.

MEDICAL PRINCIPLES AND PRACTICE, vol.29, no.5, pp.473-479, 2020 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1159/000506257
  • Journal Name: MEDICAL PRINCIPLES AND PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.473-479
  • Keywords: Colon, Food hypersensitivity, Familial Mediterranean fever, Lymphonodular hyperplasia, NODULAR LYMPHOID HYPERPLASIA, MUCOSA, IMMUNODEFICIENCY, INCREMENT, ALLERGY, TRACT
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University Affiliated: No

Abstract

Objective:We aimed to share our observations on the demographics, clinical characteristics, and outcomes of lymphonodular hyperplasia (LNH) in children.Subjects and Methods:The study included children on whom colonoscopy was performed between January 2015 and May 2018 (n= 361). Demographics, treatment modalities, and outcomes of the patients with LNH were recorded.Results:LNH was found in 66 patients (18.3%; mean age 8.6 +/- 5.96 years, 59.1% male). We found that the etiologic factors were food hypersensitivity (FH) in 25 (37.8%), nonspecific colitis in 12 (18.2%), irritable bowel syndrome in 10 (15.2%), familial Mediter-ranean fever in 7 (10.6%), primary immunodeficiency in 4 (6.1%), and intestinal dysmotility, oxyuriasis, Crohn's disease, and giardiasis in 1 (1.5%) patient. Additionally, in the genetic analysis of patients with idiopathic LNH (n= 4), we detected heterozygoteMEFVmutations in all. Cow's milk and egg (25%) were the most common allergens in patients with FH. Symptoms of all patients (n= 25) improved after an elimination diet.Conclusions:LNH is a common finding in pediatric colonoscopies with a variety of etiologies ranging from FH and familial Mediterranean fever to immunodeficiency.