Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications

CABIOĞLU N., Sahin A. A., Morandi P., Meric-Bernstam F., Islam R., Lin H. Y., ...More

ANNALS OF ONCOLOGY, vol.20, no.6, pp.1013-1019, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1093/annonc/mdn740
  • Journal Name: ANNALS OF ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1013-1019
  • Keywords: bone metastases, CCR7, CXCR4, HER2-neu, metastatic breast cancer, LYMPH-NODE METASTASIS, CELL-DERIVED FACTOR-1-ALPHA, CXCR4 EXPRESSION, GROWTH-FACTOR, HER-2 STATUS, BONE, TUMOR, AXIS, CCR7, OVEREXPRESSION
  • Istanbul University Affiliated: No

Abstract

Background: We investigated the expression of CXCR4, CCR7, estrogen receptor (ER), progesterone receptor (PR) and HER2-neu in human metastatic breast cancers to determine whether these biological biomarkers were preferentially expressed in any organ-specific metastases.