Cytotoxic, Genotoxic, and Apoptotic Effects of Nickel Oxide Nanoparticles in Intestinal Epithelial Cells

Abudayyak M. F., Guzel E., Ozhan G.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.4, pp.446-451, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2019.76376
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.446-451
  • Keywords: Nickel oxide nanoparticles, intestinal cells, genotoxicity, oxidative stress, apoptosis, ACUTE OXIDATIVE STRESS, HUMAN LIVER-CELLS, DNA-DAMAGE, INDUCE CYTOTOXICITY, NIO, ASSAY, TOXICITY, RATS
  • Istanbul University Affiliated: Yes

Abstract

Objectives: The superior properties of nickel oxide-nanoparticles (NiO-NPs) have led to their wide use in various fields. However, there is little comprehensive knowledge about their toxicity, especially after oral exposure. The toxic effect of NiO-NPs of mean size 15.0 nm was investigated in Caco-2 (human intestinal epithelial) cells as no study has been performed on their intestinal toxicity.