Cytotoxic, Genotoxic, and Apoptotic Effects of Nickel Oxide Nanoparticles in Intestinal Epithelial Cells


Abudayyak M., Guzel E. , Ozhan G.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, ss.446-451, 2020 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 17 Konu: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2019.76376
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayıları: ss.446-451

Özet

Objectives: The superior properties of nickel oxide-nanoparticles (NiO-NPs) have led to their wide use in various fields. However, there is little comprehensive knowledge about their toxicity, especially after oral exposure. The toxic effect of NiO-NPs of mean size 15.0 nm was investigated in Caco-2 (human intestinal epithelial) cells as no study has been performed on their intestinal toxicity.