Cytotoxic, Genotoxic, and Apoptotic Effects of Nickel Oxide Nanoparticles in Intestinal Epithelial Cells

Abudayyak M. F., Guzel E., Ozhan G.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, sa.4, ss.446-451, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2019.76376
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.446-451
  • Anahtar Kelimeler: Nickel oxide nanoparticles, intestinal cells, genotoxicity, oxidative stress, apoptosis, ACUTE OXIDATIVE STRESS, HUMAN LIVER-CELLS, DNA-DAMAGE, INDUCE CYTOTOXICITY, NIO, ASSAY, TOXICITY, RATS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: The superior properties of nickel oxide-nanoparticles (NiO-NPs) have led to their wide use in various fields. However, there is little comprehensive knowledge about their toxicity, especially after oral exposure. The toxic effect of NiO-NPs of mean size 15.0 nm was investigated in Caco-2 (human intestinal epithelial) cells as no study has been performed on their intestinal toxicity.