Relationship of negative symptom severity with cognitive symptoms and functioning in subjects at ultra-high risk for psychosis

Ucok A., Direk N., Kaya H., Caglar N., Cikrikcili U., Noyan H., ...Daha Fazla

EARLY INTERVENTION IN PSYCHIATRY, cilt.15, sa.4, ss.966-974, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/eip.13042
  • Dergi Adı: EARLY INTERVENTION IN PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.966-974
  • Anahtar Kelimeler: cognition, functioning, negative symptoms, ultra-high risk for psychosis, CLINICAL HIGH-RISK, NEUROCOGNITIVE PERFORMANCE, REWARD ANTICIPATION, INDIVIDUALS, SCHIZOPHRENIA, DEFICITS, ASSOCIATION, PREVENTION, AVOLITION, MEDIATE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim Negative symptoms and cognition are related with functioning in schizophrenia. However, it is not clear whether they have a similar effect in individuals at ultra-high risk (UHR) for psychosis. In this study, we aimed to explore relationship of negative symptoms with cognition and functioning cross-sectionally in people with UHR for psychosis. Methods In total, 107 people participated in this study. We assessed negative symptoms with Scale for Negative Symptoms (SANS). We applied a cognitive battery including seven tests. We evaluated functioning by using Global Assessment of Functioning Scale and work/study status as an indicator of role functioning. Results SANS scores were correlated to global functioning cross-sectionally. SANS total score was correlated to cognitive test scores related to cognitive flexibility and attention. Only Trail Making Test B (TMT B) was negatively correlated to global functioning. SANS-affective blunting and SANS-avolition scores were independently related to global functioning. There was a significant indirect effect of the TMT B and composite attention scores on global functioning through negative symptoms indicating a complete mediation. Conclusion Our findings suggest that negative symptoms, particularly avolition have an impact on functioning and the association of cognition with functioning was mediated by negative symptoms in UHR.