Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer.


Varol B. , ÇOŞKUN Ö., Karabulut S., SERIN K. R. , Asoglu O. , Albeniz I., ...Daha Fazla

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, cilt.35, ss.5575-82, 2014 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 35 Konu: 6
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s13277-014-1735-1
  • Dergi Adı: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • Sayfa Sayıları: ss.5575-82

Özet

The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosylation and NAD glycohydrolase activity levels were determined. The association of ADP-ribosylation and NAD glycohydrolase with clinical and laboratory factors and their impact on overall survival (OS) and disease free survival (DFS) were shown. The preoperative ADP-ribosylation and NAD glycohydrolase activity levels were significantly higher in patients with CRC than in the control group (p < 0.001). ADP-ribosylation and NAD glycohydrolase activity levels were correlated with tumor stage (p = 0.05, p = 0.001), stage of disease (p < 0.001, p < 0.001), serum CEA level (p < 0.001, p < 0.001), and site of lesion (p < 0.001, p < 0.001), respectively. Patients with high ADP-ribosylation had significantly unfavorable OS and DFS compared with those with lower levels (p < 0.001, p < 0.001), respectively. Moreover, the patients with high NAD glycohydrolase activity showed significantly worse OS and DFS rates, similar to ADP-ribosylation. Serum levels of ADP-ribosylation and NAD glycohydrolase activity correlate well with tumor stage, stage of disease, serum CEA level, and site of lesion. In conclusion, elevated levels of preoperative ADP-ribosylation and NAD glycohydrolase levels in serum are associated with poor prognosis in patients with CRC.