Evaluation of oxidative and nitrosative stress in relapsing remitting multiple sclerosis: effect of corticosteroid therapy

Seven A., Aslan M., Incir S., Altintas A.

FOLIA NEUROPATHOLOGICA, vol.51, no.1, pp.58-64, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5114/fn.2013.34197
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.58-64
  • Istanbul University Affiliated: Yes


This study is designed to evaluate the roles of oxidative and nitrosative stress in serum and cerebrospinal fluid (CSF) of relapsing remitting multiple sclerosis (RRMS) patients. Oxidative stress markers thiobarbituric acid reactive substances (TBARS), 8-epi-PGF2 alpha, conjugated diene and nitrosative stress markers nitrotyrosine, nitrit-nitrate were analysed in serum and CSF of 20 newly diagnosed RRMS patients before and after methyl prednysolone (MP) therapy (1000 mg/day i.v., for 5 days) and in healthy control group. TBARS and conjugated diene were analysed spectrophotometrically, nitrite-nitrate fluorometrically, 8-epi-PGF2 alpha and nitrotyrosine were measured by ELISA.