NUCLEOLAR ORGANIZING REGIONS IN THE OPERATED RAT STOMACH - RELATIONSHIP TO METAPLASIA, DYSPLASIA AND CARCINOMA


SEVEN R., MERCAN S., OZARMAGAN S., TITIZ I., SAVCI N., DOGAN O.

BRITISH JOURNAL OF SURGERY, vol.80, no.1, pp.57-59, 1993 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 1
  • Publication Date: 1993
  • Doi Number: 10.1002/bjs.1800800121
  • Title of Journal : BRITISH JOURNAL OF SURGERY
  • Page Numbers: pp.57-59

Abstract

This study investigated the role of duodenogastric reflux in rats after antecolic gastrojejunostomy. At the end of the study, adenocarcinoma was present in 43 per cent, dysplasia in 14 per cent and intestinal metaplasia in 43 per cent of animals. No such changes were found in control rats. A technique for silver staining nucleolar organizing regions (AgNORs) was applied to these lesions and to the control group. The AgNOR count gradually increased from normal gastric mucosa to carcinoma. This technique demonstrated differences in AgNOR count between normal mucosa and other lesions (adenocarcinoma, dysplasia, intestinal metaplasia) (P < 0.001). There was, however, considerable overlap among adenocarcinoma, dysplasia and metaplasia (P > 0.1).