Heme Oxygenase-1 Prevents Hyperthyroidism Induced Hepatic Damage via an Antioxidant and Antiapoptotic Pathway

Giris M., Erbil Y., Depboylu B., Mete O., Turkoglu U., Abbasoglu S. D., ...More

JOURNAL OF SURGICAL RESEARCH, vol.164, no.2, pp.266-275, 2010 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 164 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1016/j.jss.2009.04.013
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.266-275
  • Keywords: heme oxygenase, apoptosis, hyperthyroidism, liver damage, THYROID-HORMONES, RAT-LIVER, GLUTAMINE PROTECTS, OXIDATIVE STRESS, HO-1 INDUCTION, MITOCHONDRIA, APOPTOSIS, GLUTATHIONE, DISEASE, DEATH
  • Istanbul University Affiliated: Yes

Abstract

Background The exact pathogenesis of hepatic dysfunction in hyperthyroidism is still unknown We aimed to investigate the pathogenesis of liver dysfunction caused by hyperthyroidism through inducing heme oxygenase-1 (HO-1) expression, which has antioxidant and anti-apoptotic properties