Heme Oxygenase-1 Prevents Hyperthyroidism Induced Hepatic Damage via an Antioxidant and Antiapoptotic Pathway

Giris M., Erbil Y., Depboylu B., Mete O., Turkoglu U., Abbasoglu S. D., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.164, sa.2, ss.266-275, 2010 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 164 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jss.2009.04.013
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.266-275
  • Anahtar Kelimeler: heme oxygenase, apoptosis, hyperthyroidism, liver damage, THYROID-HORMONES, RAT-LIVER, GLUTAMINE PROTECTS, OXIDATIVE STRESS, HO-1 INDUCTION, MITOCHONDRIA, APOPTOSIS, GLUTATHIONE, DISEASE, DEATH
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background The exact pathogenesis of hepatic dysfunction in hyperthyroidism is still unknown We aimed to investigate the pathogenesis of liver dysfunction caused by hyperthyroidism through inducing heme oxygenase-1 (HO-1) expression, which has antioxidant and anti-apoptotic properties