A Rapid Method for the Determination of Buprenorphine and Norbuprenorphine in Urine by UPLC-MS/MS


Kul A. , Ozdemir M., Ozilhan S., Sağırlı A. O.

CURRENT PHARMACEUTICAL ANALYSIS, vol.17, no.7, pp.926-931, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.2174/1573412916999200627010536
  • Title of Journal : CURRENT PHARMACEUTICAL ANALYSIS
  • Page Numbers: pp.926-931
  • Keywords: Buprenorphine, norbuprenorphine, proficiency testing, method validation, UPLC-MS, MS, urine samples, MASS-SPECTROMETRY, UNITED-STATES, ABUSE, DRUGS, BLOOD, METABOLITES, PLASMA

Abstract

Background: Buprenorphine is quite common in the illicit market. Buprenorphine-containing drug abuse is frequently encountered in patients. The analysis methods used to determine the abuse of buprenorphine and norbuprenorphine are important for forensic science. Buprenorphine is metabolized to norbuprenorphine by the liver.