A Rapid Method for the Determination of Buprenorphine and Norbuprenorphine in Urine by UPLC-MS/MS

Kul A., Ozdemir M., Ozilhan S., Sağırlı A. O.

CURRENT PHARMACEUTICAL ANALYSIS, vol.17, no.7, pp.926-931, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.2174/1573412916999200627010536
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
  • Page Numbers: pp.926-931
  • Keywords: Buprenorphine, norbuprenorphine, proficiency testing, method validation, UPLC-MS, MS, urine samples, MASS-SPECTROMETRY, UNITED-STATES, ABUSE, DRUGS, BLOOD, METABOLITES, PLASMA
  • Istanbul University Affiliated: Yes


Background: Buprenorphine is quite common in the illicit market. Buprenorphine-containing drug abuse is frequently encountered in patients. The analysis methods used to determine the abuse of buprenorphine and norbuprenorphine are important for forensic science. Buprenorphine is metabolized to norbuprenorphine by the liver.