Electroanalytical methods for determination of antiviral drugs in pharmaceutical formulation and biological fluids: A review

Aydogmus Z., Asfoor A.

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, cilt.50, sa.10, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 50 Sayı: 10
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.cjac.2022.100063
  • Dergi Adı: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, Compendex, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: Electroanalytical methods, Modified electrodes, Determination, Antiviral drugs, Biological fluids, Pharmaceutical formulations, PULSE VOLTAMMETRIC DETERMINATION, MOLECULARLY IMPRINTED POLYMER, REDUCED GRAPHENE OXIDE, DOTS ELECTROCHEMICAL BIOTRANSDUCER, PENCIL GRAPHITE ELECTRODE, GLASSY-CARBON ELECTRODES, SQUARE-WAVE, HUMAN PLASMA, SENSITIVE DETECTION, COMPOSITE ELECTRODE
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Viruses can infect all kinds of life forms, from humans, animals and plants to microorganisms, including bacteria and archaea, and can cause serious illness, including a pandemic. Antivirals act as a blocking mechanism against the viral replication cycle at various stages to treat viral infections. Currently, antiviral therapy is available for a limited number of infections and is mainly used to minimize symptoms, further spread, and shorten the dura-tion of the illness. For this reason, it is very important to develop fast, precise and reliable methods to analyze antiviral drugs from dosage forms or biological samples. Electroanalytical methods have been used frequently in the analysis of antiviral drugs comprising of different structures. Electrochemical methods have an important place among analytical methods with their unique features such as specificity, high sensitivity, reliability, eco-nomical, easy sample preparation, and no pre-analysis process. The purpose of this review article is to compile published electrochemical methods for the determination of antiviral drugs in pharmaceutical preparations and biological fluids. In addition to these applied methods, the types of electrodes used, and the materials used in the modification and designation of these electrodes are classified and briefly explained with their limitations.