Age-related changes on glucose transport and utilization of human erythrocytes: Effect of oxidative stress

Guven M., Ozkilic A., Kanigur-Sultuybek G., Ulutin T.

GERONTOLOGY, vol.45, no.2, pp.79-82, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 2
  • Publication Date: 1999
  • Doi Number: 10.1159/000022067
  • Journal Name: GERONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.79-82
  • Istanbul University Affiliated: Yes

Abstract

Background: Normal aging is associated with an impairment in glucose homeostasis, Methods: In order to investigate the effect of aging on glucose transport and utilization in erythrocytes, the transport and utilization of glucose were measured in erythrocytes from 10 young (mean age 26 +/- 3 years) and 10 elderly (mean age 70 +/- 7 years) healthy individuals. In addition, the glucose transport and utilization were also measured in the presence of cumene hydroperoxide (CumOOH), a toxic organic hydroperoxide that is known to induce oxidative stress. Results: The levels of glucose transport and utilization were significantly lower in the elderly group than the young group (p < 0.05). The glucose transport and utilization were not altered by CumOOH treatment in either young or elderly individuals. Conclusion: These results indicate an age-related decrease in the both glucose transport and utilization in erythrocytes.