Investigation of <i>AMPD1</i> rs17602729, <i>PPAR-α</i> rs4253778, <i>ADRB2</i> rs1042713 and <i>ADRB3</i> rs4994 Polymorphisms in Diabetic Obese and Non-Obese Diabetic Groups

DURAK Ş., AKSOYER SEZGİN S. B., Dogan Z., Celik F., Gurol A. O., Ozyavuz M. K., ...Daha Fazla

CLINICAL & TRANSLATIONAL METABOLISM, cilt.24, sa.1, 2026 (ESCI, Scopus)

Özet

Gene polymorphisms influencing mechanisms such as energy metabolism, fat storage, and insulin sensitivity can contribute to or have protective effects against the development of obesity and diabetes. Therefore, understanding the impact of genetic factors on the risk of obesity and diabetes is crucial for the development of individualized treatment and prevention strategies. We aimed to investigate the factors of obesity in diabetic patients in terms of AMPD1, PPAR-alpha, ADRB2, and ADRB3 gene polymorphisms, as well as biochemical parameters. This case-control study included 99 diabetic obese patients and 99 non-obese diabetic patients. AMPD1, PPAR-alpha, ADRB2 and ADRB3 gene polymorphisms were detected using real-time polymerase chain reaction. Biochemical parameters were assayed using AU5800 Series Clinical Chemistry Analyzers. AMPD1, ADRB3, and PPAR-alpha gene polymorphisms were associated with BMI in diabetic patients (p<0.05). Non-obese diabetic patients with the G allele of the PPAR-alpha rs4253778 polymorphism showed an increase in BMI (p=0.019). In addition, carriage of the A allele of the ADRB2 rs1042713 polymorphism was associated with approximately 7-fold higher odds of obesity compared with the GG genotype (OR=7.188, 95% CI: 2.383-21.675, p<0.001), whereas carriage of the C allele of the ADRB3 rs4994 polymorphism was associated with approximately 2.5-fold higher odds of obesity compared with the TT genotype (OR=2.478, 95% CI: 1.254-4.895, p=0.008). The genetic variations observed in the studied genes, particularly their relationship with body mass index (BMI), propose a potential association with obesity risk in diabetic individuals. The development of obesity in diabetic individuals may vary from person to person, with genetic factors playing a significant role in this process.