Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay


WEBER M. L., HSIN H., KALAY E., BROZKOVA D. S., SHIMIZU T., Bayram M., ...More

BMC MEDICAL GENETICS, vol.15, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15
  • Publication Date: 2014
  • Doi Number: 10.1186/1471-2350-15-81
  • Journal Name: BMC MEDICAL GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Dental caries, Deafness, Dental development, Ear development, Linkage disequilibrium, Genetics, Polymorphisms, GENOME-WIDE ASSOCIATION, HIGH CARIES EXPERIENCE, SCAN, GENE, PREVALENCE, EXPRESSION, MUTATIONS, TYPE-1, DFNB35, ADULTS
  • Istanbul University Affiliated: Yes

Abstract

Background: Congenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience in humans.