HLA B-27 subtypes in turkish patients with spondyloarthropathy and healthy controls

Oguz F. , OCAL L., DILER A. S. , OZKUL H., ASICIOGLU F. , KASAPOGLU E., ...Daha Fazla

DISEASE MARKERS, cilt.20, ss.309-312, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1155/2004/565270
  • Sayfa Sayıları: ss.309-312


The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the Turkish population, and B*2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B*2705 among B27-positive patients and controls was significantly different (P = 0.02). Our study supports other reports from different populations which showed that B*2705 and B*2702 were more frequent in Caucasian patients with SpA.