Prediction of Molecular Subtypes Using Superb Microvascular Imaging and Shear Wave Elastography in Invasive Breast Carcinomas


ALADAĞ KURT S., KAYADİBİ Y., SARAÇOĞLU M. S., ÖZTÜRK T., KORKMAZER B., CERİT M. N., ...More

ACADEMIC RADIOLOGY, vol.30, no.1, pp.14-21, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1016/j.acra.2022.04.017
  • Journal Name: ACADEMIC RADIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.14-21
  • Istanbul University Affiliated: No

Abstract

Rationale and Objectives: To investigate the efficacy of the advanced imaging methods, superb microvascular imaging (SMI) and shear wave elastography (SWE) in predicting molecular subtypes in invasive breast carcinomas.Materials and Methods: A total of 210 biopsy-proven breast carcinomas in 200 patients who underwent ultrasound (US) imaging with SMI and SWE were included in this study. Quantitative analyses were performed using mean elasticity (Emean) score by SWE and vascular index (VI) by SMI. For qualitative assessment of microvascularity, first, lesions were graded according to Adler's classification in four types. Then, a new morphological model was used to classify the microvascular architecture into six patterns: type one, no signal; type two, pen-etrant; type three, rim-like; type four, dot-like/linear/regional; type five, wheel-like and type six, irregular signals. The correlation between these variables and molecular subtypes, nuclear grade, the Ki-67 levels and axillary status was investigated.Results: The average VI and Emean values were relatively higher in non-luminal subtypes (VI, p = 0.002; Emean, p > 0.05). The two microvas-cularisation models were significantly able to differentiate the molecular subtypes according to the Kruskal Wallis test (p < 0.05). Rim-like, penetrant and regional patterns were primarily observed in luminal subtypes. The dominant pattern in non-luminal subtypes was wheel -like pattern. VI, Emean, Adler's classification and morphological vascularisation model were not significantly correlated with the nuclear grade, Ki-67 index or axillary status. Conclusion: The proposed microvascular categorization model may be more valuable in predicting molecular subtypes of breast carcino-mas compared to VI and Emean and may contribute to the management of breast carcinomas as a non-invasive variable.(c) 2022 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.