Hyperbaric oxygen therapy as an anti-infective agent


Cimsit M. , Uzun G., Yildiz S.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, cilt.7, ss.1015-1026, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 7 Konu: 8
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1586/eri.09.76
  • Dergi Adı: EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
  • Sayfa Sayıları: ss.1015-1026

Özet

Hyperbaric oxygen therapy (HBOT) involves inhalation of 100% oxygen at supra-atmospheric ambient pressure. HBOT is used as either a primary or adjunctive treatment in the management of infections such as gas gangrene, necrotizing fasciitis, diabetic foot infections, refractory osteomyelitis, neurosurgical infections and fungal infections. HBOT acts as a bactericidal/bacteriostatic agent against anerobic bacteria by increasing the formation of free oxygen radicals. HBOT restores the bacterial-killing capacity of leukocytes in hypoxic wounds by increasing tissue oxygen tensions. In addition, HBOT acts synergistically with a number of antibiotics. This article reviews the anti-infective effects of HBOT and the use of HBOT in the treatment of certain infectious diseases.