Hyperbaric oxygen therapy as an anti-infective agent


Cimsit M. , Uzun G., Yildiz S.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, vol.7, no.8, pp.1015-1026, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 7 Issue: 8
  • Publication Date: 2009
  • Doi Number: 10.1586/eri.09.76
  • Title of Journal : EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
  • Page Numbers: pp.1015-1026

Abstract

Hyperbaric oxygen therapy (HBOT) involves inhalation of 100% oxygen at supra-atmospheric ambient pressure. HBOT is used as either a primary or adjunctive treatment in the management of infections such as gas gangrene, necrotizing fasciitis, diabetic foot infections, refractory osteomyelitis, neurosurgical infections and fungal infections. HBOT acts as a bactericidal/bacteriostatic agent against anerobic bacteria by increasing the formation of free oxygen radicals. HBOT restores the bacterial-killing capacity of leukocytes in hypoxic wounds by increasing tissue oxygen tensions. In addition, HBOT acts synergistically with a number of antibiotics. This article reviews the anti-infective effects of HBOT and the use of HBOT in the treatment of certain infectious diseases.