ANTENATAL BARTTER SYNDROME: Analysis of Two Cases with Placental Findings


Dane B., Dane C., Aksoy F. , Cetin A., Yayla M.

FETAL AND PEDIATRIC PATHOLOGY, cilt.29, sa.3, ss.121-126, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/15513811003777276
  • Dergi Adı: FETAL AND PEDIATRIC PATHOLOGY
  • Sayfa Sayıları: ss.121-126

Özet

The prenatal diagnosis of Bartter syndrome can be based on the high chloride level in the amniotic fluid. Microscopic examination of the placenta in untreated cases showed extensive mineralization in the chorionic villi in previous studies. Two cases were presented at 26-29 weeks of gestation with severe polyhydramnios. The mothers were treated with Indomethacin, KCl, and serial amniocentesis in order to reduce the amniotic fluid volume and prevent fetal hypokalemia. The microscopic examination of the placenta revealed focal calcification and acute atherosis in placental vessels. The treatment with Indomethacin in the antenatal period can prevent severe nephrocalcinosis.