Endogenous and copper-induced lipid peroxidation and antioxidant activity of serum in hypercholesterolemic subjects

Mehmetcik G., Toker G., Uysal M.

HORMONE AND METABOLIC RESEARCH, cilt.29, sa.2, ss.63-65, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1055/s-2007-978987
  • Dergi Adı: HORMONE AND METABOLIC RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.63-65
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Endogenous malondialdehyde and diene conjugate levels were increased in hypercholesterolemic subjects with serum cholesterol levels above 240 mg/dl as compared to normocholesterolemic subjects (below 20 mg/dl). A decrease in vitamin E/cholesterol and vitamin C/cholesterol ratios was observed in serum of hypercholesterolemic individuals. However, the susceptibility of serum to copper-induced lipid peroxidation and antioxidant activity were found unchanged. The present study indicates that hypercholesterolemic subjects have a high level of circulating lipid peroxides and that a higher tendency towards atherosclerosis in these subjects may be related to increased baseline levels of serum lipid peroxides.