Decreased therapeutic effects of noscapine combined with imatinib mesylate on human glioblastoma in vitro and the effect of midkine


Erguven M., Bilir A., Yazihan N., Ermis E., Sabanci A., Aktas E. , ...More

CANCER CELL INTERNATIONAL, vol.11, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2011
  • Doi Number: 10.1186/1475-2867-11-18
  • Journal Name: CANCER CELL INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded, Scopus

Abstract

Background: Glioblastoma (GBM) develops resistance to the advances in chemotherapy leading to poor prognosis and life quality. Consequently, new treatment modalities are needed. Our aims were to investigate the effects of combined noscapine (NOS) and imatinib mesylate (IM) on human GBM in vitro and the role of midkine (MK) in this new combination treatment.